Adana's international airport is so far the only airport in the region.
Adana and Mersin is well served by intercity buses and trains you will need to transfer to a local train for Mersin, though, as the main trunk line bypasses the city.
The region is connected by the motorways O-21 to north Central Anatolia, O-51 to west Cilician Mountains, O-52 to east Southeastern Anatolia, O-53 to south Hatay. There are also toll-free highways that are in fairly good condition from all directions.